Tbh, I never did things like C-x C-s single-handed, even with a full-size PC keyboard: I hit one of the Ctrl keys with one hand, and the letter key with the other.
Anyway, after years of using it intensely, I have almost stopped using emacs for various reasons. Also vi, I use only for minor editing of shell scripts or config files. For any serious amount of coding, it has been Kate for a while now. Mainly old age I guess 🙂. But its Windows-style shortcuts do work quite well on the Pro1, too. (And, of course, it's got a vim input mode, just for you 😉 ).
Back on topic: Of course, the P