Short answer: Why not? ๐
Long answer:
I have set up a quite complex system with LOS 16 and a GNU/Linux (Devuan) running in a chroot, with multiple partitions, automatically starting servers, and shared data folders. To realise that, I use all kinds of tricks to work around Android restrictions. I fear that at least some of these hacks would not work on more recent releases because of changes in the Android security mechanisms. So I would probably have to learn new ways, which is bad because I'm lazy ... ๐
LOS 16 has a nicely-integrated and low-profile root-management solution